Cartilage is avascular tissue with low metabolism and, as a consequence, with low potential for restoration. Osteoarthritis affects more than 30% of the adult population of the planet and bioengineered implants are commonly used to address the late stages of the disease. However, there are common problems with implants, including poor cell survival and differentiation, inadequate integration into the host tissue, de-differentiation of the normal cartilage and formation of fibrous tissue with unsatisfactory mechanical characteristics. Methods of addressing cartilage degeneration in earlier stages are needed.
In this webinar, Dr. Yulia Alexandrovskaya will discuss her work on thermomechanical infrared laser regeneration of cartilage. The presentation will show it is possible to restore initial hyaline type of cartilaginous tissue, even for large defects of intervertebral discs and joints. The technology of low-invasive reconstruction of spine discs has been applied successfully to over 5,000 patients in Russia and clinical trials are being planned in the United States.
The cellular mechanisms of laser-induced regeneration of hyaline cartilage however are not well understood. Dr. Alexandrovskaya's research focuses on elucidating these mechanisms. The webinar will review the complexity of physico-chemical response of the tissue to laser stimulation effect, including laser-induced transitions of bounded water, reorganization of proteoglycan macromolecules and formation of non-uniform thermal and mechanical stress fields. Several ongoing investigations using near infrared laser for restoration of interverbal disc in spinal surgery and joint cartilage in orthopaedics will be highlighted.
What You Will Learn:
• Principles of NIR laser interaction with cartilage tissue
• Novel applications of NIR laser for tissue regeneration
Who Should Attend:
• Scientists and doctors interested in laser-assisted tissue regeneration