Biosensors play an essential role in bioanalytics and diagnostics. In particular, emerging healthcare needs with global health crisis, precision medicine and point-of-care diagnostics are demanding breakthrough developments in biosensing and bioanalytical tools. Current biosensors are lacking precision, are bulky and costly, as well as require long detection times, sophisticated infrastructure and trained personnel, which limit their applications.
Hatice Altug’s BIOnanophotonic Systems Laboratory at EPFL focuses on addressing these challenges by exploiting novel optical phenomena at the nanoscale and engineering toolkits such as nanophotonics, nanofabrication and microfluidics as well as augmenting bioimaging and hyperspectral sensor architectures with data science techniques. They use photonic nanostructures based on plasmonic and all-dielectric metasurfaces that can confine light below the fundamental diffraction limit and generate strong electromagnetic fields in nanometric volumes. They have been developing unique expertise within the visible and mid-IR spectral ranges, where they use both refractive index sensing and vibrational spectroscopy methods.
In this webinar, Hatice Altug will provide an overview for biosensing and present some recent examples. For example, Altug will introduce ultra-sensitive Mid-IR biosensors based on surface enhanced infrared spectroscopy for chemical specific detection of molecules, large-area chemical imaging and real-time monitoring of protein conformations in aqueous environment. Altug will describe her lab’s effort to develop ultra-compact, portable, rapid and low-cost microarrays and their use for early disease diagnostics in real-world settings. Altug will also highlight label-free optofluidic biosensors that can perform one-of-a-kind measurements on live cells down to the single cell level, and provide their overall prospects in biomedical and clinical applications.